Human fibroblasts are derived from cultured skin explants. Human fibroblasts are from a single donor. These cells enable researchers to study skin diseases such as dermatitis, wound healing, and other diseases that are expressed in fibroblast. In addition, they may be used to study the development of skin and production of inducible pluripotent stem cells to study disease models. Fibroblasts are isolated from an individual who has been clinically diagnosed with Mucopolysaccharidoses. Mucopolysaccharidoses are a group of metabolic disorders caused by the absence or malfunctioning of lysosomal enzymes needed to break down molecules called glycosaminoglycans - long chains of sugar carbohydrates in each of our cells that help build bone, cartilage, tendons, corneas, skin and connective tissue.